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JORNADA DE PESQUISA

Explore uma coleção de publicações de pesquisa de Debora Sobreira e colaboradores, apresentando seus últimos trabalhos inovadores e remontando às suas primeiras contribuições como estudante de pós-graduação.

LISTA COMPLETA DE PUBLICAÇÕES

Li J., Zhu J., Gray O., Sobreira D.R., Wu D., Huang R.T., Miao B., Sakabe N.J., Krause M.D., Kaikkonen M.U., Romanoski C.E., Nobrega M.A., Fang Y. Mechanosensitive super-enhancers regulate genes linked to atherosclerosis in endothelial cells. J Cell Biol. 4;223:3 (2024).

Farris K.M., Senior A.M., Sobreira D.R., Mitchell R.M., Weber Z.T., Ingerslev L.R., Barrès R., Simpson S.J., Crean A.J., Nobrega M.A. Dietary macronutrient composition impacts gene regulation in adipose tissue. Commun Biol. 16;7(1):194 (2024).

Glunk, V.*, Laber, S.*, Sinnott-Armstrong, N.*, Sobreira, D.R.*, Strobel, S.M.*, Nemati, B., Ebert, H., Ott, B., Garborcauskas, G., Honecker, J., Stirling, D., Deodato, G., Laumen, H., Abdenur, N., Calabuig, V., Ocvirk, S., Pfluger, P., Cimini, .B, Carpenter, A., Dankel, S.N., Pritchard, J., Lindgren, C.M., Hauner, H., Nobrega, M.A. and Claussnitzer, M. “A non-coding variant linked to metabolic obesity with normal weight affects actin remodeling in subcutaneous adipocytes," Nat Metab. 5; 861-879 (2023). *equal contribution / alphabetic order.

Chung, J., Das, A., Sun, X., Sobreira, D.R., Leung, Y.Y,, Iguarta, C., Mozaffari, S., Chou, Y.F., Thiagalingam, S., Mez, J., Zhang, Z., Jun, G.R., Kunkle, B., Martin, E.R., Pericak-Vance, A.M., Mayeux, R., Haines, J.L., Schellenberg, G., Nobrega, M.A., Lunetta, K.L., Pinto, J.M., Wang, L.S., Ober, C., and Farrer, L.A. “Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer disease among women,” Alzheimers Dement. 10.1002/alz.12719 (2022).

Hansen, G.T.*, Sobreira, D.R.*, Joslin, A.C., Haddad, G.A., Strobel, S.M., Laber, S., Li, Y.I., Claussnitzer, M., Battaglino, R.A. and Nobrega, M.A. “Genetics of sexually dimorphic adipose distribution in humans”, Nat Genet. 5:461-470 (2023). *equal contribution.

Gray, A.O., Yoo, J., Sobreira, D.R., Jousma J., Witonsky, D., Sakabe N.J., Ying-Jie, P., Prabhakar, N.R., Fang, Y., Nobréga, M.A. and Di Rienzo, A. “A pleiotropic hypoxia-sensitive EPAS1 enhancer is disrupted by adaptive alleles in Tibetans,” Sci Adv. Nov 25;8(47):eade1942 (2022).

Joslin, A.C.*+ Sobreira, D.R.*+, Hansen, G.T., Sakabe, N.J., Aneas, I., Montefiori, L.E., Farris, K.M., Jing, G., Lehman, D., Ober, C., He, X. and Nobrega MA+. “A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci,” Nat Commun. 6;12(1):5253 (2021). *equal contribution. +corresponding author.

Aneas, I., Decker, D., Howard, C., Sobreira, D.R., Sakabe, N.J., Blaine, K., Stein, M., Hrusch, C., Montefiori, L.E., Tena, J.J., Magnaye, K., Clay, S., Gern, J., Jackson, D., Altman, M., Naurekas, E., Hogarth, D., White, S., Gómez-Skarmeta, J.L., Schoettler, N., Ober, C., Sperling, A., and Nobrega MA+. “Asthma-associated genetic variants induce IL33 differential expression through a novel regulatory region,” Nat Commun. 21;12(1):6115 (2021).

Sobreira, D.R.+, Joslin, A.C., Zhang, Q., Williamson, I., Hansen, G.T., Farris, K.M., Sakabe, N.J., Sinnott-Armstrong, N., Bozek, G., Jensen-Cody, S.O., Flippo, K.H., Ober, C., Bickmore, W.A,, Potthoff, M., Chen, M., Claussnitzer, M., Aneas, I. and Nóbrega, M.A+. “Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5,” Science. 4;372(6546):1085-1091 (2021) +corresponding author.

Sobreira, D.R.+ and Nóbrega, M,A. “Regulatory landscapes of Nppa and Nppb,” Circ Res. 8;128(1):130-132 (2021). +corresponding author.

Sakabe, N.J., Aneas, I., Knoblauch, N., Sobreira, D.R., Clark, N., Paz, C., Horth, C., Ziffra, R., Kaur, H., Liu, X., Anderson, R., Morrison, J., Cheung, V.C., Grotegut, C., Reddy, T.E., Jacobsson, B., Hallman, M., Teramo, K., Murtha, A., Kessler, J., Grobman, W., Zhang, G., Muglia, L.J., Rana, S., Lynch, V.J., Crawford, G.E., Ober, C., He, X. and Nóbrega, M.A. “Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth,” Sci Adv. 2;6(49):eabc8696 (2020).

Helling, B.A., Sobreira, D.R., Hansen, G.T., Sakabe, N.J., Luo, K., Billstrand, C., Laxman, B., Nicolae, R.I., Nicolae, D.L., Bochkov, Y.A., Gern, J.E., Nobrega, M.A., White, S.R. and Ober, C. “Altered transcriptional and chromatin responses to rhinovirus in bronchial epithelial cells from adults with asthma,” Commun Biol. 13;3(1):678 (2020).

El Khattabi, L., Zhao, H., Kalchschmidt, J., Young, N., Jung, S., Van Blerkom, P., Kieffer-Kwon, P., Kieffer-Kwon, K.R., Park, S., Wang, X., Krebs, J., Tripathi, S., Sakabe, N., Sobreira, D.R., Huang, S.C., Rao, S.S.P., Pruett, N., Chauss, D., Sadler, E., Lopez, A., Nóbrega, M.A., Aiden, E.L., Asturias, F.J., and Casellas, R. “A pliable mediator acts as a functional rather than an architectural bridge between promoters and enhancers,” Cell. 22;178(5):1145-1158.e20 (2019).

Montefiori, L.E., Sobreira, D.R., Sakabe, N.J., Aneas, I., Joslin, A.C., Hansen, G.T., Bozek, G., Moskowitz, I.P., McNally, M.E. and Nobrega, M.A. “A promoter interaction map for cardiovascular disease genetics,” Elife. 10;7:e35788 (2018).

Boogerd, C.J., Xiaoming, Z., Aneas, I., Sakabe, N.J., Zhang, L., Sobreira, D.R., Montefiori, L.E., Bogomolovas, J., Joslin, A.C., Zhou, B., Chen, J., Nobrega, M.A. and Evans, S.M. “Tbx20 is required in mid-gestation cardiomyocytes and plays a central role in atrial development,” Circ Res. 3;123(4):428-442 (2018).

Nicodemus-Johnson, J., Myers, R.A., Sakabe, N.J., Sobreira, D.R., Hogarth, D.K., Naureckas, E.T., Sperling, A.I., Solway, J., White, S.R., Nobrega, M.A., Nicolae, D.L., Gilad, Y. and Ober, C. “DNA methylation in lung cells is associated with asthma endotypes and genetic risk,” JCI Insight. 8;1(20):e90151 (2016).

Berti, F., Nogueira, J.M., Wöhrle, S., Sobreira, D.R., Hawrot, K. and Dietrich, S. “Time course and side-by-side analysis of mesodermal, pre-myogenic, myogenic and differentiated cell markers in the chicken model for skeletal muscle formation,” J Anat. 227(3):361-82 (2015).

Smemo, S., Tena, J.J., Kim, K.H., Gamazon, E.R., Sakabe, N.J., Gómez-Marín, C., Anea, I., Credidio, F.l., Sobreira, D.R., Wasserman, N.F., Lee, J.H., Puviindran, V., Tam, D., Shen, M., Son, J.E., Vakili, N.A., Sung, H.K., Naranjo, S., Acemel, R.D., Manzanares, M., Nagy, A., Cox, N.J., Hui, C.C., Gomez-Skarmeta, J.L. and Nóbrega, M.A. “Obesity-associated variants within FTO form long-range functional connections with IRX3,” Nature. 20: 371-375 (2014).

Lours-Calet, C., Alvares, L.E., El-Hanfy, A.S., Gandesha, S., Walters, E.H., Sobreira, D.R., Wotton, K.R., Jorge, E.C., Lawson, J.A., Kelsey, L.A., Tada, M., Sharpe, C., Kardon, G. and Dietrich. S. “Evolutionarily conserved morphogenetic movements at the vertebrate head-trunk interface coordinate the transport and assembly of hypopharyngeal structures,” Dev Biol. 15;390(2):231-46 (2014).

Schubert, F.R.*, Sobreira, D.R.*, Janousek, R., Alvares, L.E. and Dietrich, S., “Dact genes are chordate specific regulators at the intersection of Wnt and Tgf-beta signaling pathways,” BMC Evol Biol. 6;14:157 (2014). *equal contribution

Sensiate, L.A.*, Sobreira, D.R.*, Da Veiga, F.C., Peterlini, D.J., Pedrosa, A.V., Rirsch, T, Joazeiro, P.P., Schubert, F.R., Collares-Buzato, C.B., Xavier-Neto, J., Dietrich, S. and Alvares LE. “Dact gene expression profiles suggest a role for this gene family in integrating Wnt and TGF-beta signaling pathways during chicken limb development,” Dev Dyn. 243(3):428-39 (2013). *equal contribution

Consonni, S.R., Werneck, C.C., Sobreira, D.R., Kühne, F., Moraes, S.G., Alvares, L.E. and Joazeiro, P.P. “Elastic fiber assembly in the adult mouse pubic symphysis during pregnancy and postpartum,” Biol Reprod. 17;86(5):151, 1-10 (2012).

Alvares, L.E., Winterbottom, F.L., Jorge, E.C., Sobreira, D.R., Xavier-Neto, J., Schubert, F.R. and Dietrich, S. “Chicken dapper genes are versatile markers for mesodermal tissues, embryonic muscle stem cells, neural crest cells, and neurogenic placodes,” Dev Dyn. 1166-1178 (2009).

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