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NEWS! Débora was nominated for the 2024 Atlas of Inspiring Hispanic/Latinx Scientists.
SOBREIRA Lab
Passionate team exploring genes' architecture and function and their regulatory networks.
 GWASScatter plot of genetic variants against genomic position for GWAS, as 'Manhattan' shape peaks. |  Reporter AssaysFour circular genetic constructs for reporter assays with highlighted segments in different colors. |
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 Expression DataTwo-axis graph with scattered dots forming three clusters, representing gene expression analysis. |  Cell PhenotypingEukaryotic cell and graphical depiction of its lineage/ancestry representation for cell phenotyping. |
 Genome EditingCRISPR-Cas9 complex used in gene editing. A cloud-shaped Cas9 envelops CRISPR RNA and targets DNA. |  Genetic VariantRepresentation of genetic variants using varying-sized circles on a DNA double helix. |
 Fine MappingColorful histogram bars form two normal distribution curves for fine mapping genomic analysis. |  MouseStylized mouse profile, a common research model, showcasing head, eyes, ears, whiskers, and tail. |
 eQTLTwo-axis graph with scattered dots forming two eQTL clusters along a diagonal trendline. |  Cell ImagingA microscope for cell imaging with a flat base, vertical column, angled arm, and rotating lens. |
 Chromatin StateWrapped DNA on barrel-shaped histone proteins, enzymes, and an antibody portray chromatin states. |  3D Chromatin ConformationChromatin domains and 3D conformation interactions in the eukaryotic cell nucleus. |
 Tissue CultureA flask used in tissue culture assays is horizontally positioned with a layer of culture media. |  Research PartnersStethoscope symbolizing research partnerships, with Y-shaped tube linking ears and chest pieces. |
Our research addresses a fundamental biology question:
"How do genetic variants lead to functional changes at the molecular, cellular, and phenotypic levels?"
With an integrated approach, we study non-coding regulatory elements and their role in disease, aiming for innovative treatments and therapies to improve lives. We leverage cutting-edge tools such as data science, machine learning, single-cell analysis, disease modeling, and genetic screening in a systematic manner.
CONTACT
US
Address
Departments of Biological Chemistry
and Human Genetics
University of California
615 Charles E. Young Drive South
Los Angeles. CA 90095. USA.
Contact
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