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NEWS!  Débora was nominated for the 2024 Atlas of Inspiring Hispanic/Latinx Scientists.

SOBREIRA Lab

Passionate team exploring genes' architecture and function and their regulatory networks.

GWAS

GWAS

Scatter plot of genetic variants against genomic position for GWAS, as 'Manhattan' shape peaks.

Reporter Assays

Reporter Assays

Four circular genetic constructs for reporter assays with highlighted segments in different colors.

Expression Data

Expression Data

Two-axis graph with scattered dots forming three clusters, representing gene expression analysis.

Cell Phenotyping

Cell Phenotyping

Eukaryotic cell and graphical depiction of its lineage/ancestry representation for cell phenotyping.

Genome Editing

Genome Editing

CRISPR-Cas9 complex used in gene editing. A cloud-shaped Cas9 envelops CRISPR RNA and targets DNA.

Genetic Variant

Genetic Variant

Representation of genetic variants using varying-sized circles on a DNA double helix.

Fine Mapping

Fine Mapping

Colorful histogram bars form two normal distribution curves for fine mapping genomic analysis.

Mouse

Mouse

Stylized mouse profile, a common research model, showcasing head, eyes, ears, whiskers, and tail.

eQTL

eQTL

Two-axis graph with scattered dots forming two eQTL clusters along a diagonal trendline.

Cell Imaging

Cell Imaging

A microscope for cell imaging with a flat base, vertical column, angled arm, and rotating lens.

Chromatin State

Chromatin State

Wrapped DNA on barrel-shaped histone proteins, enzymes, and an antibody portray chromatin states.

3D Chromatin Conformation

3D Chromatin Conformation

Chromatin domains and 3D conformation interactions in the eukaryotic cell nucleus.

Tissue Culture

Tissue Culture

A flask used in tissue culture assays is horizontally positioned with a layer of culture media.

Research Partners

Research Partners

Stethoscope symbolizing research partnerships, with Y-shaped tube linking ears and chest pieces.

Our research addresses a fundamental biology question:

"How do genetic variants lead to functional changes at the molecular, cellular, and phenotypic levels?"

With an integrated approach, we study non-coding regulatory elements and their role in disease, aiming for innovative treatments and therapies to improve lives. We leverage cutting-edge tools such as data science, machine learning, single-cell analysis, disease modeling, and genetic screening in a systematic manner.

GET TO 
KNOW US

Discover our passionate team of experts dedicated to cutting-edge research and innovation. Join us on our quest for scientific advancement and exploration.

SPREADING THE WORD

Dive into the tools we employ in our ongoing research projects, where we push the boundaries of knowledge, and explore our publications, where we proudly showcase the outcomes of our dedicated efforts.

VALUES &
CULTURE

We value individuals from all backgrounds and identities, and we strive to provide a supportive space where everyone feels welcomed. Through outreach, mentoring, and a commitment to celebrating diversity, we aim to create a collaborative and equitable scientific community. 

CONTACT
US

Address

Departments of Biological Chemistry
and Human Genetics

University of California

615 Charles E. Young Drive South

Los Angeles. CA 90095. USA.

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