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FEATURED ARTICLES 

First page of the scientific article titled 'Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5' published by Science.

Sobreira, D.R.+, Joslin, A.C., Zhang, Q., Williamson, I., Hansen, G.T., Farris, K.M., Sakabe, N.J., Sinnott-Armstrong, N., Bozek, G., Jensen-Cody, S.O., Flippo, K.H., Ober, C., Bickmore, W.A,, Potthoff, M., Chen, M., Claussnitzer, M., Aneas, I. and Nóbrega, M.A+. “Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5”, Science. 4;372(6546):1085-1091 (2021).

 +corresponding author.

First page of the scientific article titled 'Genetics of sexually dimorphic adipose distribution in humans’ published by Nature Genetics.

Hansen, G.T.*, Sobreira, D.R.*, Joslin, A.C., Haddad, G.A., Strobel, S.M., Laber, S., Li, Y.I., Claussnitzer, M., Battaglino, R.A. and Nobrega, M.A. “Genetics of sexually dimorphic adipose distribution in humans”, Nature Genetics. 5:461-470 (2023).

*equal contribution.

First page of the scientific article titled 'A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci,' published by Nature Communications.

Joslin, A.C.*+ Sobreira, D.R.*+, Hansen, G.T., Sakabe, N.J., Aneas, I., Montefiori, L.E., Farris, K.M., Jing, G., Lehman, D., Ober, C., He, X. and Nobrega MA+. “A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci”, Nature Communications. 6;12(1):5253 (2021).

*equal contribution. 

+corresponding author.

Cover of Nature Metabolism features the magazine name in white letters at the top, with a background showcasing immunofluorescent photomicroscopy of adipocytes. The adipocytes have gold-yellow membranes, a green fat reservoir, and blue nuclei. In the lower left corner, the text 'From gene variants to disease mechanisms' is written in white.

Glunk, V.*, Laber, S.*, Sinnott-Armstrong, N.*, Sobreira, D.R.*, Strobel, S.M.*, Nemati, B., Ebert, H., Ott, B., Garborcauskas, G., Honecker, J., Stirling, D., Deodato, G., Laumen, H., Abdenur, N., Calabuig, V., Ocvirk, S., Pfluger, P., Cimini, .B, Carpenter, A., Dankel, S.N., Pritchard, J., Lindgren, C.M., Hauner, H., Nobrega, M.A. and Claussnitzer, M. “A non-coding variant linked to metabolic obesity with normal weight affects actin remodeling in subcutaneous adipocytes”, Nature Metabolism. 5; 861–879 (2023). 

*equal contribution / alphabetic order.

First page of the scientific article titled 'Obesity-associated variants within FTO form long-range functional connections with IRX3,' published by Nature.

Smemo, S., Tena, J.J., Kim, K.H., Gamazon, E.R., Sakabe, N.J., Gómez-Marín, C., Anea, I., Credidio, F.l., Sobreira, D.R., Wasserman, N.F., Lee, J.H., Puviindran, V., Tam, D., Shen, M., Son, J.E., Vakili, N.A., Sung, H.K., Naranjo, S., Acemel, R.D., Manzanares, M., Nagy, A., Cox, N.J., Hui, C.C., Gomez-Skarmeta, J.L. and Nóbrega, M.A. “Obesity-associated variants within FTO form long-range functional connections with IRX3”, Nature. 20, p.371-375 (2014).

First page of the scientific article titled 'A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers' published by Cell.

El Khattabi, L., Zhao, H., Kalchschmidt, J., Young, N., Jung, S., Van Blerkom, P., Kieffer-Kwon, P., Kieffer-Kwon, K.R., Park, S., Wang, X., Krebs, J., Tripathi, S., Sakabe, N., Sobreira, D.R., Huang, S.C., Rao, S.S.P., Pruett, N., Chauss, D., Sadler, E., Lopez, A., Nóbrega, M.A., Aiden, E.L., Asturias, F.J., and Casellas, R. “A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers”, Cell. 22;178(5):1145-1158.e20 (2019).

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